Wart and Wart Care

What is wart?

 

A wart (also known as verruca) is generally a small, rough tumor, typically appears on hands and feet but also other places of body, which can resemble a cauliflower or a solid blister. Warts are common, and are caused by a viral infection, specifically by the human papilloma virus (HPV) and are contagious when in contact with the skin of an infected person. It is also possible to get warts from using towels or other objects used by an infected person. They typically disappear after a few months but can last for years and can recur.

 

Types of wart

 

A range of different types of wart has been identified, varying in shape and site affected, as well as the type of human papilloma virus involved. These include:

Warts are caused by a virus called human papilloma virus or HPV. There are approximately 100 strains of human papilloma viruses. Type 1, 2, and 3 causes most of the common warts. Type 1 is associated with deep plantar (sole of the feet) and palmar warts (palm of the hand). Type 2 causes common warts, filiform warts, plantar warts, mosaic plantar warts. Type 3 causes plane warts, or commonly known as flat warts. AnoGenital Warts are caused by types 6, 11, 16, 18, 30, 31, 33, 34, 35, 39, 40 and others. HPV types 6 and 11 cause about 90% of Genital Warts cases. HPV types 16 and 18 currently cause about 70% of cervical cancer cases, and also cause some vulvar, vaginal, penile and anal cancers. Gardasil, a vaccine for HPV is designed to prevent infection with HPV types 16, 18, 6, and 11; it is claimed to prevent infections to other strains of anoGenital Warts through cross protection against other types of HPVs. HPV is associated with oral cancer, laryngeal cancers, tracheal and lung cancers.

Diagnosis and Treatments

Diagnosis of warts and their specific type should be made by a doctor or medical professional.

A variety of wart treatment methods exists. Some particular ones that may be prescribed are: salicylic acid, removal of dead skin cells on the surface (keratolysis), freezing (cryosurgery), laser treatment, curettage, topical cream, podophyllum resin paint, infrared coagulator, and application of certain other medications, chemicals, etc.

There is an Organic Medicinal Treatments newly here by Pure Healing — Body Wart Care & Genital Wart Care.

About Body Wart Care: Body Wart Care is an all natural and organic topical solution proven to quickly eradicate warts without pain or scarring. Body Wart Care is derived from certified organic anti viral plant extracts, the quality of which is flawless with unsurpassed results. This treatment exhibits the highest level of anti viral activity against HPV, the virus causing warts, as supported by published scientific data.

 

It has further been established that the extracts in Body Wart Care reduce cancerous tumor growths which can result from HPV. In addition to specific antiviral properties of this product, it is highly antibacterial and shown to have an immuneostimulant function which heightens your body’s immune system and defense parameters.

 

About Genital Wart Care: GW Care (Genital Wart Care) is an all natural and organic topical solution proven to quickly eradicate genital warts without pain or scarring. GW Care is derived from certified organic anti viral plant extracts providing unsurpassed results in the elimination of genital warts. It is important to note that the quality of this product is flawless which is critical when treating infections in the genital area. GW Care exhibits the highest level of anti viral activity against HPV, the virus causing warts, as supported by published scientific data

 

We have formulated GW Care for the exclusive treatment of warts occurring in and around the genital area. The main benefit of the anti viral organic extracts in GW Care is their proven ability to act against warts when occurring in the genital tract and their non irritant quality to genital tissue when used per instructions.

 

References: http://en.wikipedia.org/wiki/Wart;

purehealing-us

Human Papilloma Virus â?? a Review

HUMAN PAPILLOMA VIRUS â?? A REVIEW

Sameera Mohotti (BSc, MSc, MD(MA))

INTRODUCTION

HPV is one of the most common sexually transmitted viral diseases. It is

estimated that 80% of sexually active adults have been infected with one or more genital HPV types at one point of their life time. The prevalence of HPV is increasing worldwide. Although it is

difficult to estimate the overall prevalence of HPV infection, it is estimated that the prevalence could be as high as 20 million (Revzina 2005). The total health care cost associated with the screening and treatment of cervical cancer in the U.S. is estimated to be $6 billion per year (Koutsky 1997). A US sero prevalence study performed by Revizina et al revealed that the highest prevalence of

HPV is among college students and women attending STD clinics Data from clinics in Australia indicate a prevalence of 4- 13% among STD clinic attendants Following initial infection, HPV establishes latent infection, from which symptomatic recurrences may develop periodically (Revzina 2005),(Armstrong 1986).

The main aim of this review was to evaluate the current literature regarding the types of HPV, symptoms and its pathogenesis.

SPECTRUM OF HPV INFECTION

Over 200 types of HPV have been classified on the basis of their DNA sequence homology. 85 HPV genotypes are well characterized.

HPV can be grouped as high risk HPV and low risk HPV based on their association with cancer and precursor lesions. High risk HPVâ??s have a high oncogenic potentials. This group includes serotypes 16,18,31,33, 34, 35,39,45,51,52,56,58,59,66,68. Low risk HPVâ??s have less oncogenic potentials and usually results in the formation of low grade precancerous lesions. This group includes

serotypes 6, 11, 42, 43, 44. This difference in the capacity to induce malignant transformation is due to the functional difference seen in E6 and E7 proteins of the two groups (Burd 2003; Longworth and Laimins 2004).

Although many HPV infections are sub clinical, symptomatic HPV infection typically results in lesions. Each HPV serotype infects certain parts of the body and responsible for different types of lesions. According to the current classification system (Bethesda system) of HPV lesions, there are three main groups. They are anoGenital Warts, low grade squamous intraepithelial lesions (cervical / anal intraepithelial neoplasia and mild dysplasia) and high grade squamous intraepithelial lesions (moderate and severe dysplasia).Cervical/anal/vulvar/penile carcinomas usually develop from high grade squamous intraepithelial lesions (University 2001).

Genital Warts (proliferative foci of epithelial keratinocytes infected with HPV) appear as bumps or abnormal growths in the genital area. This is one of the commonest clinically recognized disease manifestations of genital HPV. These are usually found in vulva, urethra, anus, and vagina and on the cervix. Warts are extremely contagious and they occasionally lead to cancer of the cervix in

women or cancer of the penis in men (Lacey 2005).

The presence of abnormal cells on the surface of the skin is called dysplasia.

Dysplasia is not a cancer and mild dysplasia is likely to self resolve. However, mild, moderate and severe dysplasia could be progressed in to a cancer, if not detected and treated at its early stage. Studies indicate that even adolescents with low grade squamous intraepithelial lesions and high grade squamous intraepithelial lesions are also at high risk for progression to high-grade cervical abnormalities (Wright, Pinto et al. 2004).

BASIC VIROLOGY

HPV is a nonenveloped, double stranded circular DNA virus with a diameter of 5.5 nm. The genome is approximately 8 Kb in size and encased in an icosahedral capsid which is composed of 72 capsomeres. Capsid comprises of an outer protein coat which consists of two capsid proteins, L1 (major) and L2 (minor) (Sapp, Volpers et al. 1995).

HPV genome is functionally divided in to 3 regions .They are the upstream regulatory region, early region and the late region. The upstream regulatory region involves in viral replication and also controls the transcription of some sequences in the early region. The early region of the genome encompasses 6 open reading frames (ORFâ??s) named E1, E2, E4, E5, E6 and E7. These encode proteins involved in viral replication, transcription and cellular transformation. E6 and E7 regions are responsible for the oncogenic properties of HPV. The late region encompasses two ORFâ??s and these encode L1 and L2 structural proteins which is necessary for capsid production (Sapp, Volpers et

al. 1995).

PRODUCTIVE HPV INFECTION

HPV gain entry into the host cells through the basal layer of the epithelium. In initial infection HPV is present as an episome. It has been proposed that HPV-6 attaches to the host cells via ?6-intergrin in the epithelium cells; where as, HPV16 and HPV 33 attach to host cells via cell surface heparin sulphate. The papilloma viral gene expressions are linked with the differentiation stages of the epithelium and virus multiplies as it progresses through the natural epithelial cell maturation (Giroglou, Florin et al. 2001).

During viral replication, the E1 gene product (E1 protein) binds to the viral origin of replication and this result in the extra chromosomal replication of the viral genome. The E2 gene product (E2 protein) down-regulates the E6 and E7 regions to allow the normal differentiation process of the cell. The capsid genes L1 and L2 synthesize the capsid protein and envelopes each episomal DNA in a protein capsid. The E4 gene product (E4 protein) is associated with the maturation and release of papilloma virus particles(Burd 2003),(Longworth and Laimins 2004).

The productive viral stage results in flat or papillary lesions. Since the papilloma virus replication goes hand in hand with the epithelial cell differentiations, as the lesions are formed the superficial and intermediate epithelial layers would contain a large amount of viral DNA. The accumulations of viral particles in the superficial epithelial layers provoke the cells to the koilocytosis cytopathic effect. This gives rise to koilocytes, in which the cellular nucleus is displaced to the side with a ‘hollow’ appearance of the cytoplasm. The virus particles are released as dying koilocytes are shed (zur Hausen 1991; Longworth and Laimins 2004).

PATHOGENESIS OF ONCOGENIC HPV

When a person gets infected with high-risk HPV, it may take up to 20 years for the

cancer changes to appear. This persistency of HPV infection is necessary for the malignant transformation of the cells. In HPV associated benign lesions, the HPV DNA is usually located extra chromosomal where as in HPV associated cancers , the HPV DNA is usually found integrated in to host genome. Integration of high risk HPV DNA in to the host cell disrupts the E2 region. This results in the loss of normal E2 down-regulation of E6 and E7 which leads to the up-regulation of the two HPV viral oncogenes; E6 and E7.These E6 and E7 gene products has the ability to destabilize the cell growth regulatory and modify the cellular environment in which it replicates (Jan M. M. Walboomers 1999; Yoshinouchi, Hongo et al. 1999; Burd 2003).

pRB and pRb related proteins are critical components of the cell cycle as they seize the

transcription factor E2F which is necessary for the functions of the cell cycle. When E7 proteins bind to the pRB, pRB-E2F complex gets disrupted and this results in the E2F liberation. This disruption affects the normal functions of the cell. E6 viral gene product, the E6 protein, targets the immunosuppressor protein p53 (low risk HPV typeâ??s bind p53 in decreased affinity). The p53 protein prevents cells from completing the cell cycle and up-regulates genes involved in DNA repair, if it comes across any DNA damage. Another important function of the p53 protein is to instruct a cell with DNA damage to commit suicide. If the p53 function is inactivated then these damaged cells would continue to divide and accumulate mutations which would eventually lead to the formation of a tumor.

When E6 protein binds to p53, E6 associated ubiquitin ligase catalyzes ubiquitin ligase mediated p53 degradation. This destroys the tumor suppressive properties of p53 (Syrjanen 1999; Ha and Califano 2004).

The ability of E6 and E7 gene products to disrupt the cellular p53 and pRB protein functions result in, increase cell proliferation and genomic instability. Eventually the cell accumulates damaged DNA/mutations which may lead to the formation of fully transformed cancerous cells. The low risk HPVâ??s appear to be unable to integrate in to the host genome. But low risk serotypes like HPV 6, 11 may result in chromosomal instability which would lead to the accumulation of mutational events, which in turn may form fully transformed cancerous cells .In addition to the E6 and E7 protein function, methylation of viral DNA, telomere activations, humoral and immunogenic factors also contribute to the cellular transformations (Holowaty, Miller et al. 1999; Burd 2003).

REFERENCES

Armstrong, B. K., O. V. Allen, B. A. Brennan, I. A. Fruzynski, N. H. de Klerk, E. D. Waters, J.

Machin, and M. M. Gollow (1986). “Time trends in prevalence of cervical cytological abnormality in

women attending a sexually transmitted diseases clinic and their relationship to trends in sexual

activity and specific infections.” Br J Cancer 54: 669-75.

Burd, E. M. (2003). “Human Papillomavirus and Cervical Cancer.” Clin. Microbiol. Rev. 16: 1-17.

Burd, E. M. (2003). “Human Papillomavirus and Cervical Cancer.” Clin. Microbiol. Rev. 16(1): 1-17.

Giroglou, T., L. Florin, et al. (2001). “Human Papillomavirus Infection Requires Cell Surface Heparan Sulfate.” J. Virol. 75(3): 1565-1570.

Ha, P. K. and J. A. Califano (2004). “The role of Human Papilloma Virus in oral carcinogenesis.” Crit Rev Oral Biol Med 15(4): 188-196.

Holowaty, P., A. B. Miller, et al. (1999). “Natural History of Dysplasia of the Uterine Cervix.” J. Natl. Cancer Inst. 91(3): 252-258.

Jan M. M. Walboomers, M. V. J., M. Michele Manos, F. Xavier Bosch, J. Alain Kummer, Keerti V. Shah,

Peter J. F. Snijders, Julian Peto, Chris J. L. M. Meijer, Nubia Muñoz, (1999). “Human papillomavirus is a necessary cause of invasive cervical cancer worldwide.” The Journal of Pathology 189(1): 12-19.

Koutsky, P., Laura. (1997). “Epidemiology of Genital Human Papillomavirus Infection.” The American Journal of Medicine 102: 3-8.

Lacey, C. J. N. (2005). “Therapy for genital human papillomavirus-related disease.” Journal of

Clinical Virology Supplement: Human Papillomaviruses 32(Supplement 1): 82-90.

Longworth, M. S. and L. A. Laimins (2004). “Pathogenesis of Human Papillomaviruses in Differentiating Epithelia.” Microbiol. Mol. Biol. Rev. 68(2): 362-372.

Revzina, N. V., and R. J. Diclemente (2005). “Prevalence and incidence of human papillomavirus infection in women in the USA: a systematic review.” Int J STD AIDS 16: 528-37.

Sapp, M., C. Volpers, et al. (1995). “Organization of the major and minor capsid proteins in human papillomavirus type 33 virus-like particles.” J Gen Virol 76(9): 2407-2412.

Syrjanen, S. M., and K. J. Syrjanen. (1999). “New concepts on the role of human papillomavirus in cell cycle regulation.” Ann Med 31: 175-187.

University, J. s. H. (2001). “HPV-induced Anal Dysplasia: What Do We Know and What Can We Do About It?” (Online)

Wright, J. D., A. B. Pinto, et al. (2004). “Atypical Squamous Cells of Undetermined Significance in Girls and Women .” Obstet Gynecol 103(4): 632-638.

Yoshinouchi, M., A. Hongo, et al. (1999). “Analysis by Multiplex PCR of the Physical Status of Human Papillomavirus Type 16 DNA in Cervical Cancers.” J. Clin. Microbiol. 37(11): 3514-3517.

zur Hausen, H. (1991). â??Human papillomaviruses in the pathogenesis of anogenital cancer.” Virology

184: 9-13.

Warts at home treatment

My name is Lisa Mingle and like you, I have had my own very own difficult battles with warts.Their very existence literally interfered with the things I love to do, which is writing, gardening, and working with my hands, not to mention I hated the way that they looked. As a natural health practioner, I already knew about the painful and contagious nature of warts, and the predisposition of some moles to become cancerous.So you can imagine that I have tried every method available to have these taken away. I have had the extremely painful freezing and burning doctors, only to be left with a serious wound that took weeks to heal. Even with all of the pain and down time I endured, they still came back.I also spent countless dollars on useless over-the-counter products that gave me absolutely no results whatsoever. Yes, my moles and warts even defied every doctor I visited, and their expensive solutions and treatments. They were painful nuisances that got in the way of living my everyday life.I didn’t think I would EVER get rid of the moles and warts that had frustrated me for so long. Then, I finally discovered a different and viable solution to these common problems.After only three days, imagine my excitement when the moles and warts I had treated, magically dried up and disappeared! Even though I am a total skeptic…Take a look for yourself warts treatment

How to Get Rid of Warts

Genital Warts can be chemically burned or frozen with liquid nitrogen or cryosurgery. Although these techniques for freezing the infection are effective, they can cause a temporarily annoying blistering of tissue. Some cases of genital wart infection are treated by applying caustic chemicals to the infected area.Over the counter genital wart treatments containing salicylic acid are applied directly to the affected area of the Genital Warts. Consumers are then instructed to hydrate the skin in order to enhance the effects by applying warm water for five minutes prior to use. Remove any loose tissue on or around the Genital Warts and dry thoroughly. When the area is dry apply the salicylic solution. Most people who use salicyclic solutions report that the genital warts show improvement within one to two weeks. If redness, a burning sensation or irritation occurs, you should stop using the salicyclic treatments and consult your physician immediately.Usually the vinegar test when used is then combined with a standard Pap Test and the two are administered at the same time and the results compared. So, if the vinegar test yields an abnormal result, the person undergoes colposcopy (which as stated above, uses a high-powered magnification device to examination) to confirm the results.The treatment given for genital warts is invariably designed to reduce the spread of the warts in the infected person and to possible partners. The most arduous aspect of the process needs to be stressed because the warts have a tendency to reappear. Warts which are invisible but detected by a Pap test are usually only treated if the woman has multiple partners.Another method for male genital warts treatment is Electrodessication. This method burns off the genital warts, with the use of electric current. It is done in an office, usually with local anesthesia. This surgery works best when genital warts are small in number and size.Plantar warts normally start off with layers of skin at the bottom of your foot, building up in circles. They can be recognized by tiny black or brown dots, just under the surface of the skin. These warts can be found by themselves or in groups or clusters which can cover the whole sole of the foot. They can become quite painful, due to the pressure created from walking or running. A fast, effective wart remedy is therefore important.Warts are the benign overgrowth of skin cells caused by a virus called Human Papilloma Virus or HPV. This is a very common and very contagious virus. Once the person is infected, the virus chooses a moist, war place where the skin is thick and causes warts to appear. It may appear in the face, neck, knuckles, foot soles, and even the genital areas but the most common place for warts to appear is the fingers or the hand.Basically, most genital warts treatment would focus in the idea of getting rid of visible warts although despite the fact that the visible warts are eradicated, the virus would still flourish thus posing possible attacks on the future. Furthermore, treatments may or may not lessen the risk of passing the infection to someone else.Genital warts can be chemically burned or frozen with liquid nitrogen or cryosurgery. Although these techniques for freezing the infection are effective, they can cause a temporarily annoying blistering of tissue. Some cases of genital wart infection are treated by applying caustic chemicals to the infected area.Over the counter genital wart treatments containing salicylic acid are applied directly to the affected area of the genital warts. Consumers are then instructed to hydrate the skin in order to enhance the effects by applying warm water for five minutes prior to use. Remove any loose tissue on or around the genital warts and dry thoroughly. When the area is dry apply the salicylic solution. Most people who use salicyclic solutions report that the genital warts show improvement within one to two weeks. If redness, a burning sensation or irritation occurs, you should stop using the salicyclic treatments and consult your physician immediately.Usually the vinegar test when used is then combined with a standard Pap Test and the two are administered at the same time and the results compared. So, if the vinegar test yields an abnormal result, the person undergoes colposcopy (which as stated above, uses a high-powered magnification device to examination) to confirm the results.The treatment given for genital warts is invariably designed to reduce the spread of the warts in the infected person and to possible partners. The most arduous aspect of the process needs to be stressed because the warts have a tendency to reappear. Warts which are invisible but detected by a Pap test are usually only treated if the woman has multiple partners.Another method for male genital warts treatment is Electrodessication. This method burns off the genital warts, with the use of electric current. It is done in an office, usually with local anesthesia. This surgery works best when genital warts are small in number and size.Plantar warts normally start off with layers of skin at the bottom of your foot, building up in circles. They can be recognized by tiny black or brown dots, just under the surface of the skin. These warts can be found by themselves or in groups or clusters which can cover the whole sole of the foot. They can become quite painful, due to the pressure created from walking or running. A fast, effective wart remedy is therefore important.Warts are the benign overgrowth of skin cells caused by a virus called Human Papilloma Virus or HPV. This is a very common and very contagious virus. Once the person is infected, the virus chooses a moist, war place where the skin is thick and causes warts to appear. It may appear in the face, neck, knuckles, foot soles, and even the genital areas but the most common place for warts to appear is the fingers or the hand.Basically, most genital warts treatment would focus in the idea of getting rid of visible warts although despite the fact that the visible warts are eradicated, the virus would still flourish thus posing possible attacks on the future. Furthermore, treatments may or may not lessen the risk of passing the infection to someone else.

Genital Warts Treatment Method – Inexpensive Ways to Get Rid of This Problem

So what causes the problem?

Genital Warts are caused by the Human papilloma virus that spreads from one person to another through sexual contact with an infected person. It comes with a lot shame and mental anguish when you discover you have contracted the virus and so you and your sexual partner need to seek for treatment as soon as the signs are manifested. Though, waiting for the signs to appear may never be the best solution. The incubation period for the disease is anywhere between three weeks and several years. So prevention is always the best way to be safe. Looking for proper treatment is also a long journey that requires a lot of patience because it may take time before the signs subside, of course with the danger of them reappearing again and again.

Are there any affordable treatment methods?

Most people who look for affordable methods of treating their Genital Warts will always end up with a natural herbal method or some home treatment formula. But the first step is always to be sure you know what you are dealing with. The first signs are usually some itchy, painless bumps in your private parts. The men will manifest them on their penis, scrotum, thigh or anus whereas women will manifest them on their vulva, vaginal tract, thigh, cervix and anus as well. The only way to be sure what you are treating is Genital Warts are to have them examined by a qualified medical practitioner.

Herbal treatment

The world today is rediscovering the potency of natural herbs that are good for treatment and management of many health challenges. A good search on the internet will open you to the world on naturopaths and herbalists who are qualified to treat your genital warts. Some of the products they use are highly effective and because they have natural active ingredients they do not have any undesirable side effects.

Some of the best herbs that are used for the treatment of genital warts include coneflower or Echinacea which has been used by Native Americans for ages. It is also known very well for boosting the immune system thus giving the body the strength to fight the problem from inside out. You can also try the good old Goldenseal which also has very active natural ingredients. It has antibiotic qualities and is used also for treating wounds and other skin infections. Across the seas the Chinese are known for the knowledge of natural products and they have Astragalus that they use to treat HPV and other sexually transmitted infections.

Related Articles

Top rated Genital Warts Products

Genital Warts Treatments

« Previous Page — Next Page »