HIV-1 Replication Inhibited by Engineered Human Fusion Protein
September 13, 2009 by admin
In 2004, Jeremy Luban and colleagues from the University of Geneva, Switzerland, reported that New World owl monkeys (Aotus genus) make a fusion protein – AoT5Cyp – that potently blocks HIV-1 infection. The human genome encodes the equivalent of the 2 components of AoT5Cyp (i.e., TRIM5 and cyclophilin A), but humans unfortunately do not make the T5Cyp fusion protein. In their new study in the Journal of Clinical Investigation, Luban et al.
Source: HIV-1 Replication Inhibited by Engineered Human Fusion Protein
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