Complete Information on Epidermodysplasia Verruciformis With Treatment and Prevention

November 1, 2009 by admin 

Epidermodysplasia verruciformis (EV) is an uncommon inherited disease. The disease seems to be caused by several distinct man papillomaviruses. It is a lifelong, viral-mediated, autosomal recessive disorder affecting the skin. These are viruses that affect a person’s DNA. Most of these viruses are harmless to people, except to those people with epidermodysplasia verruciformis. It is believed to be caused by the human papillomavirus. Genetic predisposition is also thought to partly explain why the disease is so rare, as epidermodysplasia verruciformis papillomaviruses are often found in normal skin with no increased incidence of cancer. In the general population infection with some subtypes of human papillomaviruseshave minimal or no clinical effect, however in patients with EV, infection with these same subtypes can cause flat, wart-like lesions.

Patients typically submit early in childhood with thin wart-like lesions of the dorsal hands, extremities, confront, and neck. The disease manifests as an inborn kind in infancy, during childhood, or at puberty. The disease normally manifests as small flat warts in very young people. In most cases these warts occur in bunches numbering well over a hundred warts. The warts normally occur on sun exposed extremities, however, they can occur on any part of the body. Numerous specific human papillomavirus types have been detected in this disease. Multiple nonmelanoma skin cancers are commonly seen in such patients; thus, early diagnosis is beneficial. Patients with EV are immunotolerant towards own epidermodysplasia verruciformis human papillomaviruses throughout the whole life, whereas the oncogenic types of epidermodysplasia verruciformis human papillomaviruses induce cancers.

Epidermodysplasia verruciformis is characterized by chronic transmission with human papillomavirus. Widespread rind eruptions of flat-to-papillomatous, wartlike lesions and reddish-brown pigmented plaques on the body, the hands, the upper and lower extremities, and the cheek are normal. Skin cancers initially appear on sun-exposed areas, such as the face and the ear lobes. Patients with epidermodysplasia verruciformis have a defective cell-mediated immune response to HPV infection. Many of the HPV types found in EV lesions are nonpathogenic to the general population. Cells with early signs of malignant transformation have been found closely connected with virus-infected epidermal regions. Tumors are locally destructive without treatment. In most cases the warts occur in clusters and can be anything from a few warts to over a hundred warts.

The new handling for epidermodysplasia verruciformis includes the consumption of liquid nitrogen to suspend away the warts or by using retinoids. The new kind of handling is surgically removing the warts that move into cancer. These treatments help slow down the disease but they do not prevent new warts or cancers from forming. Surgery is also indicated for treatment of malignant lesions. Verruciformis must avoid the sun as much as possible. The UV rays from the sun are harmful to all people but it can be deadly for a person with epidermodysplasia verruciformis. Sunscreen should be applied to all exposed skin everyday. A person with this disease should eat lots of fresh fruits and vegetables, as the vitamins will help restore the skin. If a person takes these precautions it will help slow the spread of the disease. Oral and topical treatment with retinoids, fluorouracil and imiquimod are proving to be useful agents.


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