Pathophysiology For Genital Warts

Papilloma viruses are highly species specific and do not infect other species, even under laboratory conditions. Humans are the only known reservoir for HPV. Papilloma viruses are non-enveloped viruses of icosahedral symmetry with 72 capsomeres that surround a genome containing double-stranded circular DNA with approximately 8000 base pairs.

Papilloma viruses are thought to have 2 modes of replication. One is stable replication of the episomal genome in basal cells; the other is runaway, or vegetative, replication in more differentiated cells to generate progeny virus. Although all cells of a lesion contain the viral genome, the expression of viral genes is tightly linked to the state of cellular differentiation.

Most viral genes are not activated until the infected keratinocyte leaves the basal layer. Production of virus particles can occur only in highly differentiated keratinocytes; therefore, virus production occurs only at the epithelial surface where the cells are ultimately sloughed into the environment.

HPV lesions are thought to arise from the proliferation of infected basal keratinocytes. Infection typically occurs when basal cells in the host are exposed to infectious virus through a disturbed epithelial barrier as would occur during sexual intercourse or after minor skin abrasions.

HPV infections have not been shown to be cytolytic; rather, viral particles are released as a result of degeneration of desquamating cells. The HPV virus can survive for many months and at low temperatures without a host; therefore, an individual with plantar warts can spread the virus by walking barefoot.

Virus multiplication is confined to the nucleus. Consequently, infected cells exhibit a high degree of nuclear atypia. Koilocytosis (from the Greek koilos, meaning empty) describes a combination of perinuclear clearing (halo) with a pyknotic or shrunken nucleus and is a characteristic feature of productive papilloma virus infection.

The HPV genome exists as a circular episomal DNA separate from the host cell nucleus in benign or low-risk HPV lesions, such as those typically associated with HPV types 6 and 11. The genomes of high-risk HPV types 16 and 18 are typically integrated into the host cell DNA in malignant lesions.

Integration of the viral genome into the host cell genome is considered a hallmark of malignant transformation. HPV proteins E6 and E7 of high-risk serotypes have been shown to inactivate the host’s tumor suppressor proteins p53 and Rb, thereby resulting in unregulated host cell proliferation and malignant transformation.

Genital Warts can vary in appearance. They can be very small, can occur in clusters and can develop into large masses in the genital area. They seem to be as prevalent in women as men. They occur either vaginally, on the cervix, or around the anus in females. In men, they usually occur on the tip or shaft of the penis, on the scrotum or around the anus. Genital Warts cures must be able to eliminate both the visible symptoms and the causative virus to be truly effective.

Most doctors use cauterization or freezing as a first option to cure Genital Warts. Unfortunately, success achieved with this method is often temporary and the warts soon reappear. For genital warts, cures may involve having to surgically excise or burn them off. After surgical intervention or chemical acids are used, one can expect a scar in that area.

Surgical intervention as a HPV cure attempts not only to cut out the virus but also to stimulate tissue inflammation. The theory is that the body will then develop an antibody response to prevent viral recurrence. However, this method to cure genital warts often fails as doctors are unable to remove the virus in its entirety, since it commonly lodges itself deep in the dermal layers of the skin.

HPVCurative is a new, highly effective and potent way to cure genital warts. It is valued for its role in the realm of genital warts cures, and has provided total clearance of the infection time after time. It contains certified organic medicinal plant extracts and antiviral essential oils, which have demonstrated the ability to act as an HPV cure in laboratory tests. Results are guaranteed.

Users of HPVCurative experience rapid elimination of genital warts without scarring or recurrence. The treatment is painless and provides superb results when compare to other HPV cures. It eliminates genital warts and restores skin tissue to the state it was in prior to the infection. Since the treatment can effectively remove genital warts and wart-like substances on the genitals, acid or surgical HPV cures may soon become a thing of the past.

HPVCurative has powerful medicinal properties that give it an amazing ability to reduce tumor growths resulting from HPV. The organic extracts in this treatment also stimulate immune functionality, thereby strengthening the immune system. To learn more, please go to http://www.bcured.net.